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Bruker launches mass spectrometry-based tissue imaging device

The neofleX is compatible with existing Bruker software and hardware. Credit: testing / Shutterstock.

Bruker has launched its neofleX Imaging Profiler MALDI-TOF/TOF for mass spectrometry imaging (MSI) applications.

Suitable for mass spectrometry-based tissue imaging, Bruker states that the device addresses the unmet needs of moving from discovery imaging to translational and clinical tissue research.

NeofleX is also compatible with the MALDI-ISH method announced at ASMS 2024 by AmberGen.

MALDI-ISH multiplexes imaging of up to 12 oligomers of interest (RNA/DNA) for multi-omic spatial tissue research in neuroscience, infectious disease, and oncology.

In addition, the company says the neofleX excels at providing more insight per pixel through multi-omic spatial biology data from tissue sections that can positively correlate targeted proteins with glycans, metabolites, lipids, endogenous peptides, xenobiotics, and now RNA/DNA.

The neofleX is compatible with existing Bruker software and hardware, including its MALDI Imaging software and consumables ecosystems such as IntelliSlides and SCiLSautopilot – tools intended to simplify sample tracking, preparation, and analysis and to automate mass-spec imaging runs.

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According to Dr Michael Easterling, vice president of MSI for Bruker’s life sciences mass spectrometry division, the device’s multimodal software and workflows on the benchtop will support a range of biopharma and clinical research tasks.

Easterling said: “NeofleX brings novel capabilities to spatial biology, including spatial proteomics combined with unique multiomics correlations for developing actionable biological insights.”

The device’s launch follows Bruker’s recent acquisition of ELITechGroup for $942m.

Last year, Bruker entered a partnership with Advanced Diagnostics to validate the use of the company’s respective Arc and MALDI Biotyper systems.


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