MetaMedical™ Solutions Inc

Bioassay Method for Acellular Nerve Graft Potency

According to GlobalData’s company profile on AxoGen, AI-assisted MRI was a key innovation area identified from patents. AxoGen‘s grant share as of January 2024 was 29%. Grant share is based on the ratio of number of grants to total number of patents.

Bioassay method for potency of acellular nerve grafts

Source: United States Patent and Trademark Office (USPTO). Credit: AxoGen Inc

A recently granted patent (Publication Number: US11885792B2) discloses a method for conducting a bioassay of an acellular nerve graft. The method involves affixing a dorsal root ganglia (DRG) to one end of the acellular nerve graft to form a test construct, culturing the construct to allow nerve outgrowth, and analyzing the construct to determine the amount of outgrowing nerve structure. The potency of the acellular nerve graft is then determined based on the amount of outgrowing nerve structure observed.

The method includes various steps such as preparing the test construct for sectioning, staining the sections with specific stains, and analyzing the construct using diffusion tensor imaging to quantify the outgrowing nerve structure. Additionally, the method involves assaying to determine the amount of target proteins associated with the outgrowing nerve structure. The patent also covers aspects like passivating the acellular nerve graft, the duration of culturing, and the source of the acellular nerve graft, which can be from a human or an animal. Overall, the method provides a comprehensive approach to evaluating the potency of acellular nerve grafts based on the outgrowth of nerve structures, offering potential advancements in nerve regeneration research and clinical applications.

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.

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